Browsing by Author "Li, Pingwei"
Now showing items 1-20 of 43
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Geng, Zhi (2023-06-07)SARS-CoV-2 has caused a global pandemic since emerged from Wuhan, China. The Main protease of this virus is an important target for drug discovery. To test the real inhibition effect of the developed small molecule inhibitors ...
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Geng, Zhi (2023-06-07)SARS-CoV-2 has caused a global pandemic since emerged from Wuhan, China. The Main protease of this virus is an important target for drug discovery. To test the real inhibition effect of the developed small molecule inhibitors ...
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Nelson, Anna (2012-10-19)The AGC group of protein kinases (named for protein kinases A, G, and C) is found in all eukaryotes studied so far, and its members coordinate essential cellular processes including translation, metabolism, hormone response, ...
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Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response Li, Tiejun; Cheng, Hao; Yuan, Hong; Xu, Qiming; Shu, Chang; Zhang, Yuefan; Xu, Pengbiao; Tan, Jason; Rui, Yaocheng; Li, Pingwei; Tan, Xiangshi (Scientific Reports, 2016)
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Mire, Joseph Andrew (2013-07-24)β-lactamase enzymes catalyze the irreversible hydrolysis of the four-membered cyclic amide ring characteristic of β-lactam antibiotics rendering them inactive and useless against pathogenic bacteria. Understanding structure ...
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Dong, Shiyu (2020-04-20)Metallothioneins (MTs) constitute a family of cysteine-rich proteins that have the ability to bind a wide range of metal ions including Cd^2+, Zn^2+ and Ag^+ . MTs are important in metal homeostasis and detoxification. ...
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Zhou, Jinggeng (2013-07-19)Pseudomonas syringae delivers a plethora of effector proteins into host cells to sabotage host immune responses and physiology to favor infection. We have previously shown that P. syringae pv. tomato DC3000 effector HopF2 ...
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Xu, Hengyi (2015-05-13)In eukaryotes the ends of chromosomes are constituted by nucleoprotein complexes termed telomeres. Telomeres represses a DNA damage response and, more importantly, facilitate the maintenance of the terminal DNA sequence ...
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Kratch, Kaci Caitlin (2021-11-22)Chemical biology creates a unique opportunity to reexamine and alter biological processes by means of chemical manipulations. To better understand biological systems, chemical functionalities can be used to generate selective ...
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Kim, Yong-Ick (2009-05-15)The circadian oscillator of the cyanobacterium Synechococcus elongatus is composed of only three proteins, KaiA, KaiB, and KaiC, which together with ATP can generate a self-sustained ~24 hour oscillation of KaiC phosphorylation ...
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Meng, Xiangzhou (2015-05-05)DNA replication is a vital process to duplicate genetic material for inheritance. A conventional mitotic cell cycle is composed of G1, S, G2 and M phases, and DNA is replicated during S phase. Besides the conventional cell ...
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Sun, Di (2021-01-11)Posttranscriptional gene silencing (PTGS) involves two kinds of small non-coding regulatory RNAs, miRNA and small interfering RNA (siRNA) that regulate gene expression in diverse biological processes in eukaryotic organisms. ...
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Li, Xiao (2020-10-16)The Mediator complex, consisting of the head, middle, tail and CDK8 (Cyclin-Dependent Kinase 8) kinase module, is required by almost all the protein coding gene and a variety of non-coding gene transcription in eukaryotic ...
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Pang, Ting (2011-08-08)Lysis of the host by bacteriophage 21 requires two proteins: the pinholin S21 (forms pinholes in the cytoplasmic membrane and controls lysis timing) and the endolysin (degrades the cell wall). S21 has a dual-start motif, ...
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Hu, Fuqu (2014-08-13)Argonautes (AGOs) are central components in RNA-induced gene silencing complexes (RISCs) and control almost all aspects of developmental processes in eukaryotes. Study on AGO proteins not only elucidates the fundamental ...
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Cheng, Cheng (2013-11-08)Perception of evolutionarily conserved pathogen-associated molecular patterns (PAMPs) elicits rapid and profound transcriptional reprogramming in hosts and activates defense to pathogen attack. The molecular signaling ...
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Iadarola, Donna Marie (2021-04-09)How phospholipids are transported to different organelles within the cell is a major unsolved question in cell biology. To address this gap in knowledge, I utilized Saccharomyces cerevisiae as a model organism to study ...
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Yi, Guanghui; Wen, Yahong; Shu, Chang; Han, Qingxia; Konan, Kouacou; Li, Pingwei; C. Cheng Kao (Journal of Virology, 2016)
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Fu, Xuebing (Texas A&M University, 2008-10-10)Molecular dynamics simulations were conducted on a system consisting of a decamer DNA solvated by trehalose and water (molecular ratio= 1:2), to mimic a relatively dry state for the DNA molecule. Simulations were performed ...
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Qiao, Pei (2022-01-10)The structure and function of membrane proteins are often under the regulation of cofactors such as lipids and other small molecules in the biological membrane bilayer. The characterization of most membrane proteins with ...